James+Brooks'+Log

/L

September 23: I'm pretty sure I am going to the chemical compound 3,4-Methylenedioxymethamphetamine. As a fairly popular compound as a street drug, understanding its chemical properties not only would be interesting to know, it would also help me dissuade myself further from ever ingesting this compound.

September 30,2010: Thinking about going after a simpler compound for the properties assignment. I worked closely with HF on my recent co-op so I think I would enjoy researching that topic.

HF Properties:

Boiling Point: 112F http://www.alfa.com/en/GP100w.pgm?DSSTK=010989 19C http://msds.chem.ox.ac.uk/HY/hydrogen_fluoride.html

Sept. 30th: Once again I am changing my compound. Salicylic Acid is fairly simple and seems to have a lot of research and data behind it.

Salicylic Acid Properties:

Density: 1.443 g/cm^3 http://www.alfa.com/en/GP100w.pgm?DSSTK=A12253 1.443 g/cm^3 https://scifinder-cas-org.ezproxy2.library.drexel.edu/scifinder/view/scifinder/scifinderExplore.jsf (Reg #: 69-72-7) 1.443 g/cm^3 http://www.wolframalpha.com/input/?i=salicylic+acid 1.44 g/cm^3 http://www.jtbaker.com/msds/englishhtml/s0506.htm 1.44 g/cm^3 http://www.fishersci.com/msds?productName=AC419220020&productDescription=SALICYLIC+ACID%2C+REAGENT++++2KG&catNo=AC41922-0020&vendorId=VN00032119&storeId=10652

Melting Point: 161 °C http://msds.chem.ox.ac.uk/SA/salicylic_acid.html 158 °C http://chem.sis.nlm.nih.gov/chemidplus/jsp/common/PhysicalProperties.jsp 159 °C https://scifinder-cas-org.ezproxy2.library.drexel.edu/scifinder/view/scifinder/scifinderExplore.jsf (Reg #: 69-72-7) 159.5 °C http://www.wolframalpha.com/input/?i=salicylic+acid 157-159 °C http://www.chemicalland21.com/specialtychem/finechem/SALICYLIC%20ACID.htm

Boiling Point: 211 °C http://msds.chem.ox.ac.uk/SA/salicylic_acid.html 211 °C http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en&N4=S5922|SIGMA&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC 211 °C https://scifinder-cas-org.ezproxy2.library.drexel.edu/scifinder/view/scifinder/scifinderExplore.jsf (Reg #: 69-72-7) 211 °C http://www.wolframalpha.com/input/?i=salicylic+acid 211 °C http://www.jtbaker.com/msds/englishhtml/s0506.htm

Flash Point: 157 °C http://www.alfa.com/en/GP100w.pgm?DSSTK=A12253 157 °C http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en&N4=S5922|SIGMA&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC 144.5 °C https://scifinder-cas-org.ezproxy2.library.drexel.edu/scifinder/view/scifinder/scifinderExplore.jsf (Reg #: 69-72-7) 145 °C http://www.wolframalpha.com/input/?i=salicylic+acid 157 °C http://www.chemicalland21.com/specialtychem/finechem/SALICYLIC%20ACID.htm

Oral, rat: LD50: 891 mg/kg http://www.fishersci.com/msds?productName=AC419220020&productDescription=SALICYLIC+ACID%2C+REAGENT++++2KG&catNo=AC41922-0020&vendorId=VN00032119&storeId=10652 891 mg/kg http://.fao.org/docrep/x2230e/x2230e15.htm 891 mg/kg http://www.wolframalpha.com/input/?i=salicylic+acid 891 mg/kg http://www.labseeker.com/ChemicalBiotech/chem-moreinfo.asp?catalog_no=31511 891 mg/kg http://www.chemicalland21.com/specialtychem/finechem/SALICYLIC%20ACID.htm







Oct. 7, 2010: Just Finished my properties for salicylic acid. The weight of the world has been lifted off my shoulders.

Oct. 11, 2010: Posted my paper I had written previously for my paper summary.

My paper was on different methods of quantifying "club drugs" in human systems due to their increased usage.

** Trends in bioanalytical methods for the ** ** determination and quantification of club ** ** drugs: 2000–2010 **
 * Stacy D. Brown* and Tyler C. Melton **

[|Online Text]


 * · Close to 50% of college students have used club drugs in their life. This includes GHB, ketamine, methamphetamine, ecstasy and rophynol.
 * · 10% of students studied had the worst problems after taking methamphetamine. This is the second worst drug after ecstasy.
 * · MA is considered part of a worldwide drug epidemic due to how easily it is manufactured, distributed, and ingested.
 * · MA is a stimulant that may include withdrawal, irritability, physiological disorders, anorexia, and insomnia.
 * · MDMA is a stimulant and a hallucinogen. It results in mental confusion, hyperthermia, metabolic acidosis, tremors, and myoclonus.
 * · Ketamine is known to allow a ‘complete dissociation from the environment.” Amnesia is a common side effect as well as depression, elevated body temperature, and fatal respiratory issues.
 * · GHB is called a disassociative anesthetic. GHB may affect the cerebral cortex, resulting in hypnotic and anesthetic effects.
 * · Rohypnol is a sedative often used as an anesthetic and for treating insomnia.
 * · This review is for the demand of specific analytical technology for the determination and quantification of club drugs from biological matrices.
 * · The interest in this technology has increased and climaxed in 2008 with over thirty-one published methods to test for these drugs.
 * · Analysis of these drugs is mostly done through urine and drugs. Urine is preferred due to the longer amount of time allowed between the drug use and the test to receive detectable levels.
 * · Liquid-liquid extraction is the most significant preparation for club drug methods. Gas Chromatography of this extracted liquid is then preferred over all other methods.
 * · GC’s were sued over 51% of the time. The main problem is derivatization is normally a prerequisite for GC usage.
 * · MA utilized LC 32% of the time. Although, this form is more popular for ketamine due to high resolution and fast separation.
 * · Capillary electrophoresis was used 5% of the time. It was not popular due to high sensitivity in GC systems.
 * · Club Drug methods in modern society revolve around mass spectroscopy.
 * · UV and diode array detection is another popular detection technique.
 * · To convict people on drug use, quantitative methods must be contrived. LC-MS/MS has been the best way of determining this quant. Data.
 * · It is possible to detect ketamine in urine to 0.1 nq/mL using UPLC-ESI-MS/MS.
 * · Due to the use of flunitrazepam in many rape cases it is very important to have an accurate way to measure levels in humans. It may be detected to 0.02 ng/mL.
 * · Ultra-filtration of saliva is used to determine levels of GHB in human subjects.
 * · Flunitrazepam increased prevalence during the 1990’s and increased the monitoring of it.
 * · GHB emerged as a club drug in the early 1990’s and curiosity has stayed constant through the twenty-first century.
 * · MA and MDMA are incredibly studied chemicals due not only to their club and sexual harassment uses, but to their legitimate medical uses. These uses include fighting ADD/ADHD and narcolepsy.
 * · There are assays in use that can be used to determine quantitative data on multiple drugs through urine and blood samples.
 * · The interests of amphetamines, ketamines, flunitrazepam, and GHB are a growing chemical field. Newer ways of quantifying amount of drugs in a system are increasingly important as more rape cases surface.

11/27/10 - Started work on Final Paper Collected approximately 7 good sources for paper and read over them to get ideas for flow of paper

11/28/10 - Started writing paper Put together 800 words on how methamphetamine is produced, the feelings gained through taking it, and the side effects

11/29/10 - Adding a survey I had filled out on the internet Started going over research papers collected on the 27th and added a few paragraphs on each

12/4/2010 - 4:12 am - Very Tired, Entire Paper was completed on the 1st, but citations and bibliography is taking much longer than expected. Plus dealing with crtl-z problem on wikispaces. Almost done!


 * I notice the crtl-z problem as well. Finished at 3:30AM. Can't wait to write PChem labs next term.... -FXG