• Thursday, September 23, 2010- Joined the cheminfo2010 wikispace and began to think of a molecule to research. A possibility is psilocybin.

Drugs seem to be popular this year - JBB

  • Thursday, September 30, 2010- Will be researching 5 properties of the compound p-Cresol.

Assignment 1: 5 Properties of p-Cresol

Source
MP(deg.C)
BP(degC)
flash point(degC)
Density@ 25degC (g/mL)
LD50 Oral-Rat (mg/kg)
Fischer
35
202.2
86.1
1.03
207
Fischer
35
202.2
86.1
1.03
270
Oxford University
34
202
86
1.03
207
Sigma Aldrich*
32-34
202
85
1.034
207
Wolfram Alpha
33
202
89.44
1.034
207
Fischer 2
12-30
200
82
1.04
1454
SigmaAldrich.JPGSA_p-cresol_LD50.JPG

-Your style is very aesthetically pleasing to my eyes - JBB


  • Sunday, November 7, 2010- After skimming some of the journals I found, I realize that health concerns must also be taken into account when using psilocybin for medicinal purposes. Also, I see many journals are available about the detection methods of psilocybin. Since it comes from mushrooms in various quantities, detections methods are needed to establish just how much is being introduced into the body.

  • Thursday, November 11, 2010- Journal Summary:
  • Acute, Subacute and Long-Term Subjective Effects of Psilocybin in Healthy Humans: A Pooled Analysis of Experimental Studies
  • [Full marks JCB]
    1. Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is a hallucinogenic drug found in psilobe mushrooms which can be found all around the world.
    2. In 1955, psilocybin began to be researched for medicinal purposes, and in 1959, a sythetic psilocybin for reasearch pusposes.
    3. Clinical studies in the 60s and 70s demonstrated psilocybin having effects similar to those of LSD.
    4. After the high abuse of psychedelic drugs in the 60s, funding became limited for research in this field.
    5. Research resumed in the 90s with studies that used psychedelic drugs to try and determine the neural reasoning behind psychosis and other similar diseases.
    6. More current research shows improvement in anxiety of advanced stage cancer patients and obsessive compulsive disorder in rodents.
    7. This article specifically centers around the long-term subjective effects of psilocybin.
    8. Data from psilocybin experiments were pooled from the years 1999-2008.
    9. All patients receive a placebo and varying doses of psilocybin (45-315ug/kg).
    10. Vitals were monitored intermittently during the experiment.
    11. After 7 hours, all subjects were examined and released.
    12. All subjects were recruited through advertisements and people with family history of mental disorders and substance abuse were turned down.
    13. All psilocybin obtained from the Swiss Federal Office for Public Health.
    14. All subjects were subjected to the Altered States of Consciousness Rating Scale.
    15. 6 sujbects were rated by using the Adjective Mood Rating Scale.
    16. A follow-up questionnaire was given to all subjects 8-16 months after consumption.
    17. Of the 110 test subjects, 2 dropped out for non-drug related reasons and 5 subjects were removed due to adverse effects to low dosages.
    18. Results were statistically analyzed using free available computer packages.
    19. Scores in all fields of Altered States of Consciousness Rating scale increased with dosage.
    20. The Mood Rating Scale also showed increase in all fields except for tiredness.

    21. Only 90 of the 110 patients responded to the long-term questionnaire.
    22. Subjects reported no change or decrease in drug intake.
    23. 9% of subjects reported "flashback" experience.
    24. 12% of subjects reported negative changes in psychological functions. Only 8% reported these to be severe.
    25. Concluded that psilocybin produced and altered state of consciousness with no ceiling effect seenw tih high doses.
    26. Conclusion that psilocybin is well tolerated by the human body and most adverse effects disappear after 24 hours.
    27. In the long terms follow-up, 90% rated the experience to be at least mildly enriching.
    28. Significant reports of long-term change in change of attitude, relationship with he environment and aesthetic experiencing.
    29. No evidence of increase in drug abuse
  • Saturday December 4, 2010- Uploaded Interviews and completed final paper.
  • TheMagicDragon.png
  • The_Pope.png
I'm so tired... -JBB