September 30, 2010 - Week 2
For the first assignment the molecule that I picked is butyl butyrate and I will be looking at its properties.

October 7, 2010 - Week 3
Today I will be looking at the following properties of butyl butyrate,
1. Density
2. Melting point
3. Boiling point
4. Refractive index
5. Solubility in Water

October 21, 2010- Week 5
Finish working on this assignment...

1. http://en.wikipedia.org/wiki/Butyl_butyrate. The density is stated to be 0.8692g/cm^3 at 20oC.
2. http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5=SEARCH_CONCAT_PNO%7CBRAND_KEY&N4=W218618%7CALDRICH&N25=0&QS=ON&F=SPEC. Density is 0.869g/ml at 25oC (lit).
3. http://www.chemspider.com/RecordView.aspx?rid=af241699-9685-412b-88f7-c199cf754b14 In chemspider, the density of this compound is 0.878g/cm^3.
4. http://www.hbcpnetbase.com/tables/default.asp. In the handbook of chemistry and Physics, the density is 0.8700 g/cm^3 at 20oC.
5. https://fscimage.fishersci.com/msds/34099.htm. The density is listed to be 0.8870g/cm^3.

Melting Point:

1. http://www.hbcpnetbase.com/tables/default.asp. In the handbook of Chemistry and Physics, the melting point is -91.5oC
2. https://fscimage.fishersci.com/msds/34099.htm. The melting point is -92oC
3. http://en.wikipedia.org/wiki/Butyl_butyrate. The Melting point in this site is -91.5oC.
4. http://www.chemicalbook.com/ProductChemicalPropertiesCB8376985_EN.htm. Melting point is -92oC.
5. http://www.acros.be/DesktopModules/Acros_Search_Results/Acros_Search_Results.aspx?search_type=CatalogSearch&SearchString=Butyl%20butyrate. Melting point is -92oC.

Boiling Point:
1. http://en.wikipedia.org/wiki/Butyl_butyrate. The boiling point in wikipedia is 165oC.
2. http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5=SEARCH_CONCAT_PNO%7CBRAND_KEY&N4=W218618%7CALDRICH&N25=0&QS=ON&F=SPEC. Boiling point is 164-164oC (lit).
3. http://www.chemspider.com/RecordView.aspx?rid=a2be4987-1312-4327-aa53-729ccd786509. the boiling point of this compound is 165oC at 760mmHg. (This is part of the Predicted properties in ACD/Labs). Under experimental properties, the boiling point is 165-167oC.
4. http://www.hbcpnetbase.com/tables/default.asp. In the handbook of Chemistry and Physics the boiling point is 166oC.
5. https://fscimage.fishersci.com/msds/34099.htm. Boiling point is listed to be between 164-165oC.

Refractive Index:
1. http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5=SEARCH_CONCAT_PNO%7CBRAND_KEY&N4=W218618%7CALDRICH&N25=0&QS=ON&F=SPEC. Refractive index is stated to be n20/D 1.406 (lit)
2. http://www.hbcpnetbase.com/tables/default.asp. In the handbook of Chemistry and Physics, the refractive index is 1.4075.
3. http://www.chemicalbook.com/ProductChemicalPropertiesCB8376985_EN.htm. Refractive index is n20/D 1.406(lit).
4. http://www.acros.be/DesktopModules/Acros_Search_Results/Acros_Search_Results.aspx?search_type=CatalogSearch&SearchString=Butyl%20butyrate. Refractive index is listed to be between 1.405-1.407.
5. http://www.knovel.com/web/portal/knovel_content?p_p_id=EXT_KNOVEL_CONTENT&p_p_action=1&p_p_state=normal&p_p_mode=view&p_p_col_id=column-1&p_p_col_count=1&_EXT_KNOVEL_CONTENT_struts_action=/ext/knovel_content/view&_EXT_KNOVEL_CONTENT_contentType=1&_EXT_KNOVEL_CONTENT_SetID=13171328&_EXT_KNOVEL_CONTENT_SpaceID=0&_EXT_KNOVEL_CONTENT_VerticalID=0&_EXT_KNOVEL_CONTENT_BookID=1863&_EXT_KNOVEL_CONTENT_NodeID=1193943&_EXT_KNOVEL_CONTENT_SearchType=0&_EXT_KNOVEL_CONTENT_Datatype=1&_EXT_KNOVEL_CONTENT_FromToc=true&_EXT_KNOVEL_CONTENT_SearchMode=%20true&_EXT_KNOVEL_CONTENT_Random=1345196535&_EXT_KNOVEL_CONTENT_advancedSearch=false&_EXT_KNOVEL_CONTENT_searchTermA1=butyl+butyrate&_EXT_KNOVEL_CONTENT_subjectAreaID=-999&_EXT_KNOVEL_CONTENT_subSubjectAreaID=-2&_EXT_KNOVEL_CONTENT_IsSearch=true&sistring=0;;;0;;;0;;;-2;;;1863;;;0;;;null;;;-999;;;0;;;0;;;0;;;0;;;0;;;0;;;0&ststring=butyl%20butyrate;;;;;;0;;;0;;;0;;;0;;;0
Refractive index is 1.4064. This information was obtained through the Merck index online.
Flash Point:
1. http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5=SEARCH_CONCAT_PNO%7CBRAND_KEY&N4=W218618%7CALDRICH&N25=0&QS=ON&F=SPEC. The Flash point is 53oC and 127oF.
2. https://fscimage.fishersci.com/msds/34099.htm. The flash point is listed to be 49 deg C.
3. http://www.alfa.com/content/msds/English/B24390.pdf. The flash point is listed to be 49 deg C.
4. http://www.acros.be/DesktopModules/Acros_Search_Results/Acros_Search_Results.aspx?search_type=CatalogSearch&SearchString=Butyl%20butyrate. Flash point is listed to be 49oC.
5. http://www.knovel.com/web/portal/knovel_content?p_p_id=EXT_KNOVEL_CONTENT&p_p_action=1&p_p_state=normal&p_p_mode=view&p_p_col_id=column-1&p_p_col_count=1&_EXT_KNOVEL_CONTENT_struts_action=/ext/knovel_content/view&_EXT_KNOVEL_CONTENT_contentType=1&_EXT_KNOVEL_CONTENT_SetID=13171328&_EXT_KNOVEL_CONTENT_SpaceID=0&_EXT_KNOVEL_CONTENT_VerticalID=0&_EXT_KNOVEL_CONTENT_BookID=1863&_EXT_KNOVEL_CONTENT_NodeID=1193943&_EXT_KNOVEL_CONTENT_SearchType=0&_EXT_KNOVEL_CONTENT_Datatype=1&_EXT_KNOVEL_CONTENT_FromToc=true&_EXT_KNOVEL_CONTENT_SearchMode=%20true&_EXT_KNOVEL_CONTENT_Random=1345196535&_EXT_KNOVEL_CONTENT_advancedSearch=false&_EXT_KNOVEL_CONTENT_searchTermA1=butyl+butyrate&_EXT_KNOVEL_CONTENT_subjectAreaID=-999&_EXT_KNOVEL_CONTENT_subSubjectAreaID=-2&_EXT_KNOVEL_CONTENT_IsSearch=true&sistring=0;;;0;;;0;;;-2;;;1863;;;0;;;null;;;-999;;;0;;;0;;;0;;;0;;;0;;;0;;;0&ststring=butyl%20butyrate;;;;;;0;;;0;;;0;;;0;;;0
it is listed to be 53.5oC. Merck index was the source.

Now that I am done gathering all the information that I needed for this compound, I created a Table to summarize the results:

November 10, 2010
Today I worked on the FAQ assignment due on 11/18/2010.
The question that I answered was Q.11.

11. Compare in detail the merits of Scifinder, Web of Science and Google Scholar.


Google Scholar:

In Google Scholar you can find academic materials such as peer-reviewed papers, theses, books, abstracts, and technical reports from various areas of research.

Merits of Google Scholar

It is a reliable search tool to browse and access some of the academic literature. It is a free and openly accessible tool for academic literature .
Many articles are available full-text.
Google Scholar is able to connect to library resources.
The sources are more academic than those you would find through a standard search engine query
It has a wide range of academic content areas and is updated constantly.
It ranks and lists results according to how relevant they are to the search query. The most relevant references tend to appear at the top of the page.
You can access articles the library has on campus or off through the use of a VPN.
Web of Science:
It includes only the most influential, relevant and credible journal information available.
It has a diverse multidisciplinary coverage (approximately 8,830 titles indexed from 230 disciplines), which facilitates discovery by allowing the user to find answers in places that could have been overlooked.
It covers many journals back to 1900, including issues of significant publications.
Every item within a journal is indexed, including full papers, editorials, reviews, letters, and more.
Its backfile collection makes it over 100 years of valuable research available. This unique collection is also cross searchable with other ISI Web of Knowledge resources.
It delivers cited reference data that is accurate, consistent and without redundancies.
It has an analyze tool that allows the user to discover emerging areas of current investigation in the sciences and social sciences. This tools lets the user refine searches by grouping results by author, publication year, institution, subject category, document type, source title, language, or country.
The major resource to find chemistry articles and patents from around the world as well as reputable sources.
Reference to more than 10,000 currently published journals and patents from more than 61 patent authorities.
Important scientific discoveries from the present to the mid-1800s.
The latest scientific breakthroughs almost as soon as they are published with references added daily and some patent information as recent as 2 days ago
The world’s largest collection of organic and inorganic substance information.
Access to current, high-quality scientific information
Links to more relevant journal articles and patent documents than any other source.
Content indexed by scientists.
An intuitive interaction
Time savings, with speedy access to more than a century of scientific information
A novel approach to problem solving by linking related concepts
An online version of Chemical Abstracts
A keyword, references, and abstracts database (CAPLUS)
A substance database (REGISTRY)
A reaction databases (CASREACT)


November 10, 2010
Today I also finished my article summary. For my research paper I will be talking about epidermal growth factor receptor. I will be discussing its biology, its function, and its applications to cancer research.

Assignment 2: Article Summary
Review of Epidermal Growth Factor Receptor Biology
Roy S. Herbst, M.D., Ph.D.
Int. J. Radiation Oncology Biol. Phys., Vol. 59, No. 2, Supplement, pp. 21-26, 2004
Doi: 10.1016/j.ijrobp.2003.11.041
[Full marks JCB]

· The differences between cancer cells and noncancerous cells have been studied and well described over the years. Recently, research efforts have focused on understanding the cellular events that culminate in the transformation of normal cells to malignant cells. These differences are significant because a much more effective tumor-specific therapy could be developed.
· These newly developed therapies would avoid or minimize the toxicity associated with chemotherapy. This would be done by focusing mainly on key molecules that are integral for cellular function, replication, or tumorigenisis.
· Growth factor receptors make part of such class of targets, and the therapies that are directed against these proteins have shown promising results in tumors.
· An important growth factor receptor is the epidermal growth factor receptor (EGFR). EGFR is a transmembrane glycoprotein which makes part of the erbB family of tyrosine kinase receptors. It plays an important role in the regulation of cell proliferation, differentiation, and survival of epithelial cells and tumors of epithelial cell origin. These roles make EGFR an interesting molecule to study, since interfering with its activities can interrupt signaling transduction.
· The over expression of EGFR helps to distinguish tumor cells from normal cells, making it possible for EGFR-inhibitory molecules to be more selective on tumor cells and attenuate their aggressive proliferation.
· To date there are two way to target the EGFR to interfere with EGFR-mediated cellular effects. The first one consists of monoclonal antibodies to block ligand binding to the extracellular portion of EGFR and the second approach involves small molecule compounds that interfere with intracellular EGFR tyrosine kinase activity.
· Based on experiments performed, it appears that monoclonal antibodies exhibit greater specificity for the EGFR compared with some of the small molecule compounds.
· Unfortunately, the monoclonal antibodies have the potential to induce an immune antibody response to the monoclonal antibody that could cause future therapies with the antibody to be ineffective. They may also be ineffective against altered forms of EGFR.
· Some of the most effective EGFR inhibitory compounds that have advanced to clinical stages of development are IMC-C225, ABX-EGF, ICR-62, and EMD-72000, which are all monoclonal antibodies, and the tyrosine kinase inhibitors are ZD1839, OSI-774, and CI-1033.
· The data obtained shows that these drugs represent an opportunity to improve cancer treatment, especially for those tumors characterized by EGFR over expression.

November 11, 2010
Today I finished entering the 5 properties of butyl butyrate into the validation table. Missing links and broken links were also taken care of. Since I am done with most of the work up to now. I will be working on my research paper.